HRID2362358

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2757009

6-bromopyridine-2-carbaldehyde

C6H4BrNO

HCID11064685

Diethyl (4-Fluorobenzyl)phosphonate

C11H16FO3P

结构：COc1cccc([C@H]2OC(=O)N[C@@H]2c2cncc(Br)c2)c1

HCID69086194

未命名化合物

PRODUCTS

生成物

结构：O=C1N[C@H](c2cccc(Br)n2)[C@@H](c2ccc(F)cc2)O1

HCID86673415

未命名化合物

PROCEDURE

实验过程

Prepared according to the same procedure as optically-enriched (4R,5R)-4-(5-bromopyridin-3-yl)-5-(3-methoxyphenyl)oxazolidin-2-one, starting with 6-bromopicolinaldehyde and diethyl 4-fluorobenzylphosphonate. 1H-NMR (CDCl3, 500 MHz) δ 7.65 (dd, J=7.9, 7.6, 1H), 7.51 (d, J=7.6, 1H), 7.46 (dd, J=8.9, 5.2, 2H), 7.41 (d, J=7.6, 1H), 7.13 (m, 3H), 5.61 (d, J=7.5, 1H), 4.90 (d, J=5.8, 1H). 13C-NMR (CDCl3, 126 MHz) δ 163.1 (d, J=249), 159.4 (d, J=55), 142.6, 139.8, 134.0, 128.3, 127.8, 127.7, 119.6, 116.2, 116.0, 83.1, 64.4.

WORKUP

后处理

customPrepared