HCID 69085480, compound → HCID 86673429, compound

HRID 2362392Notes

Reaction equation

HRID 2362392 reaction equation
Br[C:2]1C=NC=[C:6](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[F:17])[CH:7]=1.[Br:18][C:19]1[N:24]=C(CP(=O)(OCC)OCC)C=C[N:20]=1>>[Br:18][C:19]1[N:24]=[C:6](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[F:17])[CH:7]=[CH:2][N:20]=1

Participants

3

Reactant 2

HCID 69085480HCID 69085480, compoundHCID 86673426HCID 86673426, compound

Product 1

HCID 86673429HCID 86673429, compound

Procedure

Prepared according to the same procedure as (E)-3-bromo-5-(2,5-difluorostyryl)pyridine, starting with diethyl (2-bromopyrimidin-4-yl)methylphosphonate. 1H NMR (500 MHz, DMSO-d6) δ 8.70 (d, J=5.2 Hz, 1H), 7.93 (d, J=16.2 Hz, 1H), 7.83 (ddd, J=9.3, 5.8, 3.2 Hz, 1H), 7.72 (d, J=5.2 Hz, 1H), 7.46 (d, J=16.2 Hz, 1H), 7.43-7.30 (m, 2H), Mass spec.: 299.1 (MH)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f83b5e6085f7451eacb643386cae0bb7
Source dataset
uspto-grants-2014_04
Patent number
US08691821B2

Reaction notes

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