HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 89123991, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 69281835 | HCID 69281835 | — |
| Reactant | HCID 89136642 | HCID 89136642 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 89123991 | HCID 89123991 | — |
Reaction Steps
Prepared according to the same procedure as (1R,2R)-2-amino-2-(5-bromopyridin-3-yl)-1-(2,5-difluorophenyl)ethanol, starting with tert-butyl(1R,2R)-1-(6-chloropyrimidin-4-yl)-2-(3-fluorophenyl)-2-hydroxyethylcarbamate. Analytical HPLC method: Phenomenex LUNA C18, 50×2 3μ, A=90% H2O/10% CH3CN, B=90% CH3CN/10% H2O, Modifier 0.1% TFA, 0.00 min=0% B, 4.0 min=100% B, 5.0 min=100% B, Flow rate=0.8 mL/min., TR=1.460 min, Mass spec.: 268.1 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691821B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-a109b4d4c8fa4685b5c27f5177236b85 |
| Source note | uspto-grants-2014_04 |