HCID 12968071, compound → HCID 86673450, compound

HRID 2362430Notes

Reaction equation

HRID 2362430 reaction equation
BrC1N=C(C[P:9](=[O:16])([O:13][CH2:14][CH3:15])[O:10][CH2:11][CH3:12])C=CC=1.[Br:17][C:18]1[CH:19]=[C:20]([CH2:25]O)[C:21]([F:24])=[N:22][CH:23]=1>>[CH2:11]([O:10][P:9]([CH2:25][C:20]1[C:21]([F:24])=[N:22][CH:23]=[C:18]([Br:17])[CH:19]=1)(=[O:16])[O:13][CH2:14][CH3:15])[CH3:12]

Participants

3

Reactant 2

HCID 12968071HCID 12968071, compoundHCID 69084872(5-Bromo-2-fluoropyridin-3-yl)methanol

Product 1

HCID 86673450HCID 86673450, compound

Procedure

Prepared according to the same procedure as diethyl (6-bromopyridin-2-yl)methylphosphonate, starting with (5-Bromo-2-fluoropyridin-3-yl)methanol. 1H-NMR (CDCl3, 500 MHz) δ: 8.18 (d, J=1.2 Hz, 1H), 7.94 (dt, J=8.4, 2.5 Hz, 1H), 4.10-4.16 (m, 4H), 3.10-3.20 (m, 2H), 1.31 (t, J=7.2 Hz, 6H). 13C-NMR (CDCl3, 126 MHz) δ: 147.1, 144.5, 117.0, 116.5, 62.7, 26.9, 25.7, 16.5. Mass spec.: 328.0 (MH)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6db48bf2d84c4ba1903469eb53035868
Source dataset
uspto-grants-2014_04
Patent number
US08691821B2

Reaction notes

Loading…