HRID2362461

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C1N[C@H](c2cc(C#Cc3ccccc3)cnc2F)[C@@H](c2cc(F)ccc2F)O1

HCID69082915

未命名化合物

结构：COc1ncc(C#Cc2ccccc2)cc1[C@H]1NC(=O)O[C@@H]1c1cccc(F)c1

HCID69086137

未命名化合物

PRODUCTS

生成物

结构：COc1ncc(C#Cc2ccccc2)cc1[C@H]1NC(=O)O[C@@H]1c1cc(F)ccc1F

HCID69083515

未命名化合物

PROCEDURE

实验过程

Prepared according to the same procedure as (4R,5R)-5-(3-fluorophenyl)-4-(2-methoxy-5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one, starting with ((4R,5R)-5-(2,5-difluorophenyl)-4-(2-fluoro-5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one. 1H NMR (CDCl3) δ: 8.33 (d, J=2.1 Hz, 1H), 7.83 (d, J=1.8 Hz, 1H), 7.50-7.54 (m, 2H), 7.33-7.38 (m, 3H), 7.20-7.25 (m, 1H), 7.03-7.10 (m, 2H), 6.06 (s, 1H), 5.54 (d, J=5.2 Hz, 1H), 4.98 (d, J=5.2 Hz, 1H), 3.88 (s, 3H). 19F NMR (CDCl3) δ: −119.97-115.26 (m, 1F), −123.84 (br. s., 1F). Mass spec.: 407.1 (MH)+.

WORKUP

后处理

customPrepared