1,1,1-Trimethoxybutane → HCID 68933325, compound

Participants

Reaction Steps

The general method described in Step 3 of Example 15 was used to cyclize N4-(2,2-diethoxyethyl)quinoline-3,4-diamine (26.5 g, 96.2 mmol) by reaction with trimethyl orthobutyrate (15.9 g, 107 mmol) to provide 1-(2,2-diethoxyethyl)-2-propyl-1H-imidazo[4,5-c]quinoline (25.4 g) as a dark oil that was used directly in the next step without further purification.

Provenance & Evidence