8-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine → HCID 67250174, compound

HRID 2362607Notes

Reaction equation

HRID 2362607 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([NH:13][CH2:14][CH2:15][CH3:16])[CH2:9][CH2:8]2.[N:17]1[N:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]2=[CH:19][C:18]=1[CH2:26][C:27](O)=O>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([N:13]([CH2:14][CH2:15][CH3:16])[CH2:27][CH2:26][C:18]1[CH:19]=[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]3[N:17]=1)[CH2:9][CH2:8]2

Participants

3

Reactant 2

HCID 127414178-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amineHCID 58438481HCID 58438481, compound

Product 1

HCID 67250174HCID 67250174, compound

Procedure

Synthesis works according to the preparation of A4-1 or A4-4 when using N-(8-methoxytetralin-2-yl)-N-propylamine (A2-1: R=OMe) and 2-pyrazolo[1,5-a]pyridinyl acetic acid (A3-12: R=OMe, Cy=2-pyrazolo[1,5-a]pyridinyl) (synthesis according to literature: Awano, K. Chem Pharm Bull 1992, Vol 40, p 631; Lober, S Bioorg Med Chem Lett 2002, Vol 12, p 2377) and subsequent reaction according to the synthesis of A5-1.

Workup

  1. customSynthesis
  2. customworks according to the preparation of A4-1 or A4-4 when
  3. customaccording to the synthesis of A5-1

Sources & evidence

ORD record
ord-040e5f9199524a60a1bfe496d0b822a2
Source dataset
uspto-grants-2014_04
Patent number
US08691839B2

Reaction notes

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