Chlorobenzene → HCID 58270296, compound

Participants

Reaction Conditions

Reaction Steps

5,5-diethoxy-N-(3-methylisothiazol-5-yl)pent-2-ynamide (0.700 g, 2.5 mmol) was dissolved in chlorobenzene (2.5 mL, 2.5 mmol), and to the solution was added 6-(1-azidoethyl)-3-(2-methoxyethoxy)quinoline (0.68 g, 2.5 mmol). The mixture was heated to 100° C. overnight and then increased to 110° C. for 5.5 h. The reaction was concentrated in vacuo. The compound was purified via MPLC (eluting with 0-40% EtOAc in hexanes) to yield 5-(2,2-diethoxyethyl)-3-(1-(3-(2-methoxyethoxy)quinolin-6-yl)ethyl)-N-(3-methylisothiazol-5-yl)-3H-1,2,3-triazole-4-carboxamide.

Provenance & Evidence