Bicarbonate Ion → HCID 67003360, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred ambient solution of 5-(5-chloro-2-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(3-(4-methoxybenzyloxy)oxetan-3-yl)thiazole (Example 11G) (200 mg, 0.282 mmol) and 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)morpholine (120 mg, 0.395 mmol) in N,N-dimethylformamide (2.65 mL) was added saturated aqueous bicarbonate solution (0.883 mL) followed by bis(triphenylphosphine)palladium dichloride (13.88 mg, 0.020 mmol). The mixture was heated to 70° C. for 4 hours and was then quenched by the addition of water and ethyl acetate. The layers were separated, and the aqueous layer was extracted with additional ethyl acetate. The combined organics were dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel, eluting with a gradient of 0 to 30% ethyl acetate in hexane, to afford the title compound. MS ESI(+) m/z 757.2 [M+H]+.

Provenance & Evidence