Trifluoroacetic acid → HCID 67002707, compound

Participants

Reaction Steps

To an ambient solution of 4-(4-(5-chloro-4-(2-(3-(4-methoxybenzyloxy)oxetan-3-yl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)benzyl)morpholine (Example 11H) (130 mg, 0.172 mmol) in dichloromethane (2.5 mL) was added trifluoroacetic acid (2.5 mL, 32.4 mmol). The reaction was stirred for 0.5 hours and was then concentrated to dryness under reduced pressure. The residue was partitioned between ethyl acetate (5 mL) and saturated aqueous bicarbonate solution (1 mL). The layers were separated, and the organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel, eluting with a gradient of 0 to 10% methanol in dichloromethane, to give the title compound. MS ESI(+) m/z 637.1 [M+H]+.

Provenance & Evidence