HCID 67002764, compound → HCID 67002733, compound

HRID 2362635Notes

Reaction equation

HRID 2362635 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][N:7]1[CH:11]=[C:10]([C:12]2[N:34]([S:35]([C:38]3[CH:44]=[CH:43][C:41]([CH3:42])=[CH:40][CH:39]=3)(=[O:37])=[O:36])[C:15]3=[N:16][CH:17]=[C:18]([Cl:33])[C:19]([C:20]4[S:24][C:23]([C:25]5([O:29]COC)[CH2:28][CH2:27][CH2:26]5)=[N:22][CH:21]=4)=[C:14]3[CH:13]=2)[CH:9]=[N:8]1.ClC1C(C2SC(C3(OCOC)CCC3)=NC=2)=C2C=C(C3C=NN(CCN4CCOCC4)C=3)N(S(C3C=CC(C)=CC=3)(=O)=O)C2=NC=1>>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][N:7]1[CH:11]=[C:10]([C:12]2[N:34]([S:35]([C:38]3[CH:39]=[CH:40][C:41]([CH3:42])=[CH:43][CH:44]=3)(=[O:36])=[O:37])[C:15]3=[N:16][CH:17]=[C:18]([Cl:33])[C:19]([C:20]4[S:24][C:23]([C:25]5([OH:29])[CH2:28][CH2:27][CH2:26]5)=[N:22][CH:21]=4)=[C:14]3[CH:13]=2)[CH:9]=[N:8]1

Participants

3

Reactant 2

HCID 67002764HCID 67002764, compoundHCID 67003839HCID 67003839, compound

Product 1

HCID 67002733HCID 67002733, compound

Procedure

The title compound was prepared as described in Example 1H, substituting 5-(2-(1-(1,3-dioxolan-2-yl)methyl)-1H-pyrazol-4-yl)-5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole (Example 13A) for 4-(2-(4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine (Example 1G). MS ESI(+) m/z 612.1 [M+H]+.

Sources & evidence

ORD record
ord-7e6dbff49d574cc8a531473c8594f233
Source dataset
uspto-grants-2014_04
Patent number
US08691810B2

Reaction notes

Loading…