Methanol → HCID 67003553, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)benzoic acid (Example 16A) (700 mg, 1.122 mmol) in tetrahydrofuran (9.3 mL) and 10% aqueous HCl solution (1.9 mL) was heated to 65° C. for 24 hours. An additional 3 mL 10% aqueous HCl solution and 3 mL methanol were added, and the reaction was heated to 80° C. for 3 hours. The reaction was removed from the heat bath and allowed to slowly cool to room temperature. The reaction was diluted with 5 mL water, and the solid was filtered and air-dried to yield the title compound. MS ESI(+) m/z 580.1 [M+H]+;

Provenance & Evidence