反应详情

With 2 ml of ethanol was mixed 1 g of 2-{[2-(dimethylamino)methyl-4-thiazolyl]methylthio}ethylamine and 1.1 g of 2-nitromethylene-5-phenyl-oxazolidine, and the resulting mixture was subjected to reaction under reflux for 1 hour. After completion of the reaction, the reaction mixture was filtered with cooling, and the solvent was removed by distillation under reduced pressure, after which the resulting residue was purified by a column chromatography (Wako Silica Gel C-200, eluent:chloroform:ethanol=20:1 by volume) to obtain 1.3 g (yield 68%) of N-{2-[[2-(dimethylamino)methyl-4-thiazolyl]methylthio]ethyl}-N'-(β-hydroxyphenethyl)-2-nitro-1,1-ethenediamine having a melting point of 100°-101° C.

1. customthe resulting mixture was subjected to reaction
2. temperatureunder reflux for 1 hour
3. customAfter completion of the reaction
4. filtrationthe reaction mixture was filtered
5. temperaturewith cooling
6. customthe solvent was removed by distillation under reduced pressure
7. customafter which the resulting residue was purified by a column chromatography (Wako Silica Gel C-200, eluent:chloroform:ethanol=20:1 by volume)