HCID 67003675, compound → HCID 67003417, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting N-(4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl)-2-(dimethylamino)acetamide (Example 23C) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (500 MHz, DMSO-d6) ppm 12.49 (s, 1H) 9.88 (s, 1H) 8.31 (s, 1H) 8.25 (s, 1H) 7.95 (d, 2H) 7.78 (d, 2H) 6.99 (s, 1H) 6.68 (s, 1H) 3.09 (s, 2H) 2.63 (m, 2H) 2.40 (m, 2H) 2.29 (s, 6H) 1.99 (m, 2H); MS ESI(+) m/z 482.0 [M+H]+.

Provenance & Evidence