Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 67003444 | HCID 67003444 | — |
| Reactant | HCID 178418416 | HCID 178418416 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 67003656 | HCID 67003656 | — |
Reaction Steps
In a 50 ml pressure bottle, a solution of Example 1F (0.15 g, 0.238 mmol) and triethylamine (0.066 ml, 0.476 mmol) in methanol (2 ml) and acetonitrile (2 mL) was treated with [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.017 g, 0.024 mmol). The mixture was pressurized with carbon monoxide (60 psi), and stirred at 60° C. for 4 hours. The reaction was cooled to ambient temperature and concentrated under reduced pressure. The concentrate was purified by flash chromatography on silica gel, eluting with dichloromethane, to provide the title compound. MS ESI(+) m/z 562.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08691810B2 |
|---|
| Source dataset | uspto-grants-2014_04 |
|---|
| ORD ID | ord-2c9522145e244c698cc9b289efced5e9 |
|---|
| Source note | uspto-grants-2014_04 |
|---|
