Sodium Hydroxide → HCID 67003507, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of Example 46A (0.134 g, 0.238 mmol) in methanol (2.5 mL) was treated with 2 M aqueous sodium hydroxide solution (0.714 mL, 1.19 mmol). The reaction was heated at 75° C. for 40 minutes, cooled to ambient temperature, and concentrated under reduced pressure. The residue was suspended in water (2 mL), and the pH adjusted to ˜4 with 1 N aqueous HCl solution. The suspension was filtered, and the solid collected was washed with water and dried in a vacuum oven at 60° C. to provide the title compound. ESI(+) m/z 393.9 [M+H]+.

Provenance & Evidence