Hydroxylamine → 1-tert-Butyloxycarbonyl-4-(N-Hydroxycarbamimidoyl)piperidine

Participants

Reaction Conditions

Reaction Steps

A solution of tert-butyl 4-cyanopiperidine-1-carboxylate (0.5 g, 2.378 mmol) in ethanol (12 mL) was treated with hydroxylamine (50% in water, 0.51 mL, 8.32 mmol). The reaction was heated at 80° C. for 1.5 hours. The reaction was cooled to ambient temperature and concentrated under reduced pressure. The concentrate was dried to constant weight in a vacuum oven at 60° C. to provide the title compound. DCI(+) m/z 244.1 [M+H]+.

Provenance & Evidence