HCID 67003474, compound → HCID 67003897, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting N-(4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-3-methylphenyl)-2-(dimethylamino)acetamide (Example 48C) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (500 MHz, DMSO-d6) ppm 12.28 (s, 1H) 9.80 (s, 1H), 8.34 (s, 1H) 8.23 (s, 1H) 7.64 (m, 2H) 7.52 (d, 1H) 6.67 (s, 1H) 6.61 (s, 1H) 3.09 (s, 2H) 2.62 (m, 2H) 2.44 (s, 3H) 2.40 (m, 2H) 2.29 (s, 6H) 1.96 (m, 2H); MS ESI(+) m/z 496.1 [M+H]+.

Provenance & Evidence