HCID 67003528, compound → HCID 67003667, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting N-(4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-methoxyphenyl)-2-(dimethylamino)acetamide (Example 49C) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (500 MHz, DMSO-d6) ppm 12.54 (s, 1H) 9.53 (s, 1H) 8.31 (m, 2H) 8.27 (s, 1H) 7.70 (d, 1H) 7.61 (dd, 1H) 7.08 (s, 1H) 6.68 (s, 1H) 3.99 (s, 3H) 3.10 (s, 2H) 2.63 (m, 2H) 2.42 (m, 2H) 2.32 (s, 6H) 1.99 (m, 2 H); MS ESI(+) m/z 512.1 [M+H]+.

Provenance & Evidence