Hydrochloric Acid → HCID 67002734, compound

Participants

Reaction Conditions

Reaction Steps

A solution of Example 52C (0.083 g, 0.118 mmol) in tetrahydrofuran (0.8 mL) was treated with 10% aqueous HCl solution (0.25 mL), and the reaction was heated at 65° C. for 4 hours. The reaction was cooled to ambient temperature and concentrated under reduced pressure. The concentrate was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The aqueous layer was extracted with additional ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to provide the title compound. MS ESI(+) m/z 662.2 [M+H]+.

Provenance & Evidence