HCID 67003696, compound → HCID 67003650, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting N-(4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-3-fluorophenyl)-2-(dimethylamino)acetamide (Example 60C) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (400 MHz, DMSO-D6) ppm 12.49 (s, 1H) 10.12 (s, 1H) 8.37 (s, 1H) 8.22 (s, 1H) 7.95 (m, 1H) 7.84 (dd, 1H) 7.59 (dd, 1H) 6.90 (d, 1H) 6.69 (s, 1H) 3.12 (s, 2H) 2.63 (m, 2H) 2.41 (m, 2H) 2.29 (s, 6H) 1.99 (m, 2H); MS ESI(+) m/z 500.1 [M+H]+.

Provenance & Evidence