HCID 67003892, compound → HCID 67003637, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting N-(3-chloro-4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl)-2-(dimethylamino)acetamide (Example 61C) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (400 MHz, DMSO-d6) ppm 12.45 (s, 1H) 10.10 (s, 1H) 8.38 (s, 1H) 8.23 (s, 1H) 8.06 (d, 1H) 7.73 (m, 2H) 6.89 (s, 1H) 6.68 (s, 1H) 3.12 (s, 2H) 2.61 (m, 2H) 2.40 (m, 2H) 2.29 (s, 6H) 1.97 (m, 2H); MS ESI(+) m/z 518.0 [M+H]+.

Provenance & Evidence