HCID 67003442, compound → HCID 67003688, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting N-(2-chloro-4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl)-2-(dimethylamino)acetamide (Example 63D) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (400 MHz, DMSO-d6) ppm 12.59 (s, 1H) 9.86 (s, 1H) 8.33 (s, 1H) 8.29 (s, 1H) 8.27 (s, 1H) 8.26 (d, 1H) 8.00 (dd, 1H) 7.17 (s, 1H) 6.69 (s, 1H) 3.15 (s, 2H) 2.63 (m, 2H) 2.42 (m, 2H) 2.36 (s, 6H) 1.99 (m, 2H); MS ESI(+) m/z 516.1 [M+H]+.

Provenance & Evidence