HCID 67003855, compound → HCID 67002779, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting N-(4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorophenyl)-2-(dimethylamino)acetamide (Example 64C) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (400 MHz, DMSO-d6) ppm 12.57 (s, 1H) 9.63 (s, 1H) 8.34 (s, 1H) 8.27 (s, 1H) 8.10 (t, 1H) 8.01 (dd, 1H) 7.85 (dd, 1H) 7.15 (s, 1H) 6.68 (s, 1H) 3.14 (s, 2H) 2.64 (m, 2H) 2.42 (m, 2H) 2.32 (s, 6H) 198 (m, 2H); MS ESI(+) m/z 500.1 [M+H]+.

Provenance & Evidence