HCID 67002490, compound → Benzenamine, 4-[5-chloro-4-[2-[1-(methoxymethoxy)cyclobutyl]-5-thiazolyl]-1H-pyrrolo[2,3-b]pyridin-2-yl]-3-methoxy-

HRID 2362682Notes

Reaction equation

HRID 2362682 reaction equation
[Cl:1][C:2]1[C:3]([C:30]2[S:34][C:33]([C:35]3([O:39][CH2:40][O:41][CH3:42])[CH2:38][CH2:37][CH2:36]3)=[N:32][CH:31]=2)=[C:4]2[CH:10]=[C:9]([C:11]3[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][C:12]=3[O:18][CH3:19])[N:8](S(C3C=CC(C)=CC=3)(=O)=O)[C:5]2=[N:6][CH:7]=1.ClC1C(C2SC(C3(O)CCC3)=NC=2)=C2C=C(C3C=NN(CCN4CCOCC4)C=3)N(S(C3C=CC(C)=CC=3)(=O)=O)C2=NC=1>>[Cl:1][C:2]1[C:3]([C:30]2[S:34][C:33]([C:35]3([O:39][CH2:40][O:41][CH3:42])[CH2:38][CH2:37][CH2:36]3)=[N:32][CH:31]=2)=[C:4]2[CH:10]=[C:9]([C:11]3[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][C:12]=3[O:18][CH3:19])[NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 67002490HCID 67002490, compoundHCID 67003780HCID 67003780, compound

Product 1

HCID 67003895Benzenamine, 4-[5-chloro-4-[2-[1-(methoxymethoxy)cyclobutyl]-5-thiazolyl]-1H-pyrrolo[2,3-b]pyridin-2-yl]-3-methoxy-

Procedure

The title compound was prepared as described in Example 1I, 4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3-methoxyaniline (Example 68B) for 1-(5-(5-chloro-2-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol (Example 1H). MS ESI(+) m/z 471.0 [M+H]+.

Sources & evidence

ORD record
ord-1f87a7bf12bd44769ad8e34bd7a6f1a2
Source dataset
uspto-grants-2014_04
Patent number
US08691810B2

Reaction notes

Loading…