HCID 67003465, compound → HCID 67003446, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting N-(4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-3-methoxyphenyl)-2-(dimethylamino)acetamide (Example 68D) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (500 MHz, DMSO-d6) ppm 12.10 (s, 1H) 9.89 (s, 1H) 8.30 (s, 1H) 8.22 (s, 1H) 7.81 (d, 1H) 7.61 (d, 1H) 7.44 (dd, 1 H) 6.97 (d, 1H) 6.67 (s, 1H) 3.89 (s, 3H) 3.10 (s, 2H) 2.63 (m, 2H) 2.41 (m, 2H) 2.30 (s, 6H) 1.97 (m, 2H); MS ESI(+) m/z 512.0 [M+H]+.

Provenance & Evidence