HCID 67002717, compound → HCID 67003566, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting 5-(5-chloro-2-(4-(tetrahydrofuran-3-yloxy)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole (Example 69C) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (500 MHz, DMSO-d6) ppm 12.47 (s, 1H) 8.29 (s, 1H) 8.25 (s, 1H) 7.94 (d, 2H) 7.02 (d, 2H) 6.95 (d, 1H) 6.67 (s, 1H) 5.11 (m, 1H) 3.93-3.75 (m, 4H) 2.63 (m, 2H) 2.41 (m, 2H) 2.26 (m, 1H) 1.97 (m, 3H); MS ESI(+) m/z 468.0 [M+H]+.

Provenance & Evidence