HCID 67003425, compound → HCID 67003591, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting 5-(5-chloro-2-(4-((tetrahydrofuran-2-yl)methoxy)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole (Example 70B) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (500 MHz, DMSO-d6) ppm 12.45 (s, 1H) 8.29 (s, 1H) 8.25 (s, 1H) 7.94 (d, 2H) 7.04 (d, 2H) 6.94 (d, 1H) 6.66 (s, 1H) 4.17 (m, 1H) 4.00 (m, 2H) 3.79 (m, 1H) 3.69 (m, 1H) 2.63 (m, 2H) 2.41 (m, 2H) 1.80-2.06 (m, 5H) 1.69 (m, 1H); MS ESI(+) m/z 482.0 [M+H]+.

Provenance & Evidence