HCID 67003573, compound → HCID 67003563, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting 5-(2-(4-((1,4-dioxan-2-yl)methoxy)phenyl)-5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole (Example 71B) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (500 MHz, DMSO-d6) ppm 12.46 (s, 1H) 8.29 (s, 1H) 8.25 (s, 1H) 7.94 (d, 2H) 7.04 (d, 2H) 6.95 (d, 1H) 6.66 (s, 1H) 4.03 (m, 2H) 3.85 (m, 2H) 3.78 (m, 1H) 3.65 (m, 2H) 3.51 (m, 1H) 3.42 (m, 1H) 2.63 (m, 2H) 2.40 (m, 2H) 1.97 (m, 2H); MS ESI(+) m/z 498.0 [M+H]+.

Provenance & Evidence