HCID 67003422, compound → HCID 67003901, compound

HRID 2362688Notes

Reaction equation

HRID 2362688 reaction equation
[Cl:1][C:2]1[C:3]([C:35]2[S:39][C:38]([C:40]3([O:44][CH2:45][O:46][CH3:47])[CH2:43][CH2:42][CH2:41]3)=[N:37][CH:36]=2)=[C:4]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)=[CH:13][CH:12]=3)[N:8](S(C3C=CC(C)=CC=3)(=O)=O)[C:5]2=[N:6][CH:7]=1.ClC1C(C2SC(C3(OCOC)CCC3)=NC=2)=C2C=C(C3C=NN(C)C=3)N(S(C3C=CC(C)=CC=3)(=O)=O)C2=NC=1>>[Cl:1][C:2]1[C:3]([C:35]2[S:39][C:38]([C:40]3([O:44][CH2:45][O:46][CH3:47])[CH2:41][CH2:42][CH2:43]3)=[N:37][CH:36]=2)=[C:4]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH:18]4[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]4)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 67003422HCID 67003422, compoundHCID 67003618HCID 67003618, compound

Product 1

HCID 67003901HCID 67003901, compound

Procedure

The title compound was prepared as described in Example 47B, 5-(5-chloro-2-(4-(1-methylpiperidin-4-yloxy)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole (Example 72A) for 5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole (Example 47A). MS ESI(+) m/z 539.0 [M+H]+.

Sources & evidence

ORD record
ord-065c1abccf92400f903b389ad34d6770
Source dataset
uspto-grants-2014_04
Patent number
US08691810B2

Reaction notes

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