HCID 67003901, compound → HCID 54672939, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22E, substituting 5-(5-chloro-2-(4-(1-methylpiperidin-4-yloxy)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole (Example 72B) for 1 tert-butyl 3-(3-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (Example 22D). 1H NMR (500 MHz, DMSO-d6) ppm 12.46 (s, 1H) 8.28 (s, 1H) 8.24 (s, 1H) 7.92 (d, 2H) 7.04 (d, 2H) 6.93 (d, 1H) 6.68 (s, 1H) 4.47 (m, 1H) 2.63 (m, 4H) 2.41 (m, 2H) 2.23 (m, 2H) 2.20 (s, 3H) 1.96 (m, 4H) 1.66 (m, 2H); MS ESI(+) m/z 495.0 [M+H]+.

Provenance & Evidence