HCID 86741307, compound → HCID 178457515, compound

HRID 236269Notes

Reaction equation

HRID 236269 reaction equation
CS[C:3](=[N:8][CH:9]([CH3:11])[CH3:10])[S:4]([O-:7])(=[O:6])=[O:5].[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:20]=[CH:21][NH:22][CH:23]=2)=[CH:15][CH:14]=1>C(#N)C>[CH:9]([NH:8][C:3]([S:4]([OH:7])(=[O:6])=[O:5])=[N:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[N:20]=[CH:21][NH:22][CH:23]=2)=[CH:17][CH:18]=1)([CH3:11])[CH3:10]

Participants

4

Reactant 2

HCID 86741307HCID 86741307, compoundHCID 178507418HCID 178507418, compound

Product 1

HCID 178457515HCID 178457515, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A solution of 1-methylthio-1-isopropylimino-methanesulfonate (6.8 g) in acetonitrile (150 ml) was added slowly to a solution of 4-(4-amino phenyl)-1-H-imidazole (5 g) in acetonitrile (250 ml) at room temperature. The reaction mixture was stirred overnight, and the product which crystallized out was collected by filtration to give the crude title compound, which was purified via its maleate in 95% ethanol. M.p. 209° C. (dec.).

Workup

  1. customthe product which crystallized out
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-fe614166703d41288afb29084b7bbcb5
Source dataset
uspto-grants-1987_02
Patent number
US04643993

Reaction notes

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