HCID 67003874, compound → HCID 54674222, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 8D, substituting 1-(5-(5-chloro-2-(1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol (Example 84B) 1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol (Example 8C). 1H NMR (300 MHz, DMSO-d6) δ 12.36 (bs, 1H), 8.55 (dd, J=5.0, 1.6 Hz, 1H), 8.45 (s, 1H), 8.23 (s, 1H), 8.19 (s, 1H), 8.13 (s, 1H), 7.83-7.77 (m, 1H), 7.34 (ddd, J=7.5, 4.8, 0.9 Hz, 1H), 7.18 (d, J=7.8 Hz, 1H), 6.80 (s, 1H), 6.65 (s, 1H), 5.48 (s, 2H), 2.67-2.55 (m, 2H), 2.44-2.32 (m, 2H), 2.06-1.86 (m, 2H); MS ESI(+) m/z 463.0 [M+H]+.

Provenance & Evidence