反应详情

To a solution of 36 g (0.60 mole) of dimethylhydrazine and 150 ml of benzene was added portionwise 60 g (0.25 mole) of 5-(p-chlorophenyl)-2-furoyl chloride with the temperature being controlled below 50° by means of an ice bath. The reaction mixture was refluxed for 2 hours with dissolution, cooled and the resulting precipitate filtered, washed with water and dried at 60° to yield 48 g (73%). An analytical sample was prepared by recrystallizing a sample from ethyl acetate/Darco and drying in the vacuum pistol at room temperature, m.p. 150°-152°.

1. custombeing controlled below 50° by means of an ice bath
2. temperatureThe reaction mixture was refluxed for 2 hours with dissolution
3. temperaturecooled
4. filtrationthe resulting precipitate filtered
5. washwashed with water
6. customdried at 60°
7. customto yield 48 g (73%)
8. customAn analytical sample was prepared
9. customby recrystallizing a sample from ethyl acetate/Darco
10. customdrying in the vacuum pistol at room temperature