Acetic Acid → HCID 67003523, compound

Participants

Reaction Steps

To an ambient solution of 3-(5-(5-chloro-2-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)pyrrolidin-3-ol (Example 117D) (410 mg, 0.682 mmol) in tetrahydrofuran (10 mL) was added formaldehyde (0.254 mL, 3.41 mmol, 37 wt % in water) and acetic acid (0.195 mL, 3.41 mmol). The reaction was stirred at room temperature for 20 minutes, and sodium triacetoxyborohydride (0.723 g, 3.41 mmol) was added in a single portion. The reaction was stirred at room temperature for 1 hour and was quenched by the addition of water and chloroform. The layers were separated, and the aqueous layer was extracted with additional chloroform (2×). The combined organics were dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purifed by flash column chromatography on silica gel, wluting with a gradient of 0 to 8% methanol (containing 1% v/v ammonium hydroxide) in dichloromethane, to give the title compound. MS APCI(+) m/z 614.9 (M+H)+.

Provenance & Evidence