Sodium borohydride → HCID 58513754, compound

Participants

Reaction Steps

To an ambient solution of tert-butyl 3-(2-methoxy-2-oxoethoxy)-3-(thiazol-2-yl)pyrrolidine-1-carboxylate (2.05 g, 5.99 mmol) in methanol (29.9 ml) was added NaBH4 (0.680 g, 17.96 mmol). The reaction was stirred for 1 hour and was then quenched by the addition of water (20 mL) and ethyl acetate (20 mL). The layers were separated, and the aqueous layer was extracted with additional ethyl acetate (2×20 mL). The combined organic layers were dried with anhydrous Na2SO4, filtered, and concentrated under reduced pressure to give the title compound, which was used in the subsequent step without further purification. MS ESI(+) m/z 314.9 [M+H]+.

Provenance & Evidence