N,N-Dimethylglycine → HCID 67003626, compound

Participants

Reaction Steps

A solution of Example 146C (0.048 g, 0.088 mmol), 2-(dimethylamino)acetic acid (0.011 g, 0.102 mmol), N-methylmorpholine (0.019 mL, 0.177 mmol), and 1-hydroxybenzotriazole hydrate (0.007 g, 0.044 mmol) in N,N-dimethylformamide (1 mL) was treated with N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (0.025 g, 0.133 mmol), and the reaction was stirred at ambient temperature for 6 hours. The reaction was partitioned between ethyl acetate and water. The aqueous layer was extracted with additional ethyl acetate. The combined organic layers were washed with water and brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The material was used directly in the next step without further purification. MS APCI(+) m/z 627.4 [M+H]+.

Provenance & Evidence