反应详情

A solution of 80 mg (0.20 mmol) of ((3R)—N-(4′-aminobiphenyl-4-yl)quinuclidine-3-carboxamide dihydrochloride (Example 7A) and 71.7 mg (0.41 mmol) of phenylsulfonyl chloride in 1.0 ml of pyridine is stirred at room temperature for 18 h. The reaction mixture is concentrated in vacuo and the residue is purified by preparative HPLC. The product fractions are concentrated, mixed with 3 ml of 1 N hydrochloric acid, again concentrated and dried under high vacuum. 52 mg (51.5%0 of theory) of the title compound are obtained.

1. concentrationThe reaction mixture is concentrated in vacuo
2. customthe residue is purified by preparative HPLC
3. concentrationThe product fractions are concentrated
4. additionmixed with 3 ml of 1 N hydrochloric acid
5. concentrationagain concentrated
6. customdried under high vacuum