HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(1H-pyrazol-1-yl)-4(3H)-quinazolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Tetramethoxypropane | HCID 66019 | — |
| Reactant | 2-Hydrazinyl-3,4-dihydroquinazolin-4-one | HCID 135449613 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(1H-pyrazol-1-yl)-4(3H)-quinazolinone | HCID 135782160 | 70.2% |
Reaction Steps
A mixture of 35.2 g (0.2 mole) of 2-hydrazino-4(3H)-quinazolinone, 250 ml of water, 30 ml of methanol and 36.6 ml of concentrated hydrochloric acid is stirred with 36.08 g (0.22 mole) of 1,1,3,3-tetramethoxy-propane at 40° C. The desired product precipitates after a short time from the solution initially formed. After a reaction of one hour in total at 40° C., 29.8 g of 2-(1H-pyrazol-1-yl)-4(3H)-quinazolinone (melting point 148°-50°) are isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04644000 |
| Source dataset | uspto-grants-1987_02 |
| ORD ID | ord-0fc4c51cdf1440039f2684d846d024a6 |
| Source note | uspto-grants-1987_02 |