HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-methyl-1H-pyrazol-1-yl)-4(3H)-quinazolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 3-(Dimethylamino)-2-methyl-2-propenal | HCID 565862 | — |
| Reactant | 2-Hydrazinyl-3,4-dihydroquinazolin-4-one | HCID 135449613 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-methyl-1H-pyrazol-1-yl)-4(3H)-quinazolinone | HCID 135782162 | — |
Reaction Steps
149.2 g (1.32 moles) of 2-methyl-3-dimethylaminoacrolein are added all at once to a mixture, stirred at 40° C., of 211.2 g (1.2 moles) of 2-hydrazino-4(3H)-quinazolinone, 1.5 litres of water, 540 ml of methanol and 220 ml of concentrated hydrochloric acid. The suspension is stirred at 40° for a total of 4.5 hours and at 60° for 1.5 hours. The crude 2-(4-methyl-1H-pyrazol-1-yl)-4(3H)-quinazolinone isolated at room temperature is obtained in an amount of 245 g of melting point 169°-71°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04644000 |
| Source dataset | uspto-grants-1987_02 |
| ORD ID | ord-df115ada26fd4e3096de79d3a7845aa0 |
| Source note | uspto-grants-1987_02 |