HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 136066331, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-(2-Methoxyethoxy)-1H-pyrazole | HCID 13563347 | — |
| Reactant | 2-(Methylsulfanyl)quinazolin-4(1H)-one | HCID 135427104 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 136066331 | HCID 136066331 | 58.5% |
Reaction Steps
96 g (0.5 mole) of 2-methylthio-4(3H)-quinazolinone are stirred in 250 ml of dimethylformamide with 142 g (1 mole) of 4-(β-methoxy-ethoxy)pyrazole at the reflux temperature for 40 hours. After cooling, 2.5 litres of water are added and a pH value of 3 is established with hydrochloric acid. The crude product which separates out (97.3 g of melting point 119°-24°) is recrystallized from isopropanol. 83.8 g of 2-(4-β-methoxyethoxy-1H-pyrazol-1-yl)-4(3H)-quinazolinone of melting point 125° to 127° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04644000 |
| Source dataset | uspto-grants-1987_02 |
| ORD ID | ord-907e8ea32f5841feb1027446b48fdfae |
| Source note | uspto-grants-1987_02 |