p-Chlorophenacyl bromide → HCID 86633313, compound

HRID 2362843Notes

Reaction equation

HRID 2362843 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[CH:5]=[CH:6][CH:7]=[N:8][NH:9][C:10]([NH2:12])=[S:11].Br[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=1)=O>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([C:18]2[N:12]=[C:10]([NH:9][N:8]=[CH:7]/[CH:6]=[CH:5]/[C:4]3[CH:3]=[C:2]([OH:1])[CH:15]=[CH:14][CH:13]=3)[S:11][CH:17]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 68303p-Chlorophenacyl bromideHCID 86633314HCID 86633314, compound

Product 1

HCID 86633313HCID 86633313, compoundYield 39%

Procedure

The compound is prepared according to the method described in example 1B from 3-hydroxycinnamaldehyde thiosemicarbazone (0.5 mmoles) prepared in step 15A and from 2-bromo-4′-chloroacetophenone (0.5 mmoles). Yield 39%.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-ce166a70d5d94ff3b737df039c895595
Source dataset
uspto-grants-2014_04
Patent number
US08691854B2

Reaction notes

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