Cinnamaldehyde, thiosemicarbazone → HCID 15950491, compound

HRID 2362846Notes

Reaction equation

HRID 2362846 reaction equation
[CH:1](=[N:10][NH:11][C:12]([NH2:14])=[S:13])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Br[CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][C:20]=1[CH3:26])=O>>[CH3:26][C:20]1[CH:21]=[C:22]([OH:25])[CH:23]=[CH:24][C:19]=1[C:17]1[N:14]=[C:12]([NH:11]/[N:10]=[CH:1]/[CH:2]=[CH:3]/[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[S:13][CH:16]=1

Participants

3

Reactant 2

HCID 2737765Cinnamaldehyde, thiosemicarbazoneHCID 178121702-Bromo-1-(4-hydroxy-2-methylphenyl)ethanone

Product 1

HCID 15950491HCID 15950491, compoundYield 36%

Procedure

The compound is prepared according to the method described in example 1B from cinnamaldehyde thiosemicarbazone (0.28 mmoles) (Eur. J. Med. Chem. 25(7), 581-588, 1990) and from 2-bromo-4′-hydroxy-2′-methylacetophenone (0.28 mmoles). Yield 36%.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-7a3c8a3399034aa49a16fe97c0101eb6
Source dataset
uspto-grants-2014_04
Patent number
US08691854B2

Reaction notes

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