2-Bromo-4'-(trifluoromethyl)acetophenone → HCID 86633319, compound

HRID 2362848Notes

Reaction equation

HRID 2362848 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[CH:6]=[CH:7][CH:8]=[N:9][NH:10][C:11]([NH2:13])=[S:12].Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=1)=O>>[F:28][C:27]([F:29])([F:30])[C:24]1[CH:23]=[CH:22][C:21]([C:19]2[N:13]=[C:11]([NH:10][N:9]=[CH:8]/[CH:7]=[CH:6]/[C:5]3[CH:4]=[C:3]([CH2:2][OH:1])[CH:16]=[CH:15][CH:14]=3)[S:12][CH:18]=2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 3219792-Bromo-4'-(trifluoromethyl)acetophenoneHCID 86633320HCID 86633320, compound

Product 1

HCID 86633319HCID 86633319, compoundYield 37%

Procedure

The compound is prepared according to the method described in example 1B from 3-hydroxymethylcinnamaldehyde thiosemicarbazone (0.4 mmoles) prepared in step 28A and from 2-bromo-4′-trifluoromethylacetophenone (0.4 mmoles). Yield 37%.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-6d37d5a9fbf34958a5c34ab086b02433
Source dataset
uspto-grants-2014_04
Patent number
US08691854B2

Reaction notes

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