反应详情

To a solution of benzyl 3-(2-(tert-butoxycarbonyl)benzyl)-1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate (1.5 g, 2.61 mmol) in methanol (25 mL), was added 10 wt % palladium on carbon (0.25 g). After stirring under hydrogen at room temperature and atmospheric pressure for 2 hours, the reaction mixture was filtered, washed with methanol, concentrated in vacuo to obtain tert-butyl 2-((1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate (1.1 g, 96%).

1. filtrationthe reaction mixture was filtered
2. washwashed with methanol
3. concentrationconcentrated in vacuo