Ethanol → 1H-Purine-2,6-dione, 3,7-dihydro-3-(2,2-dimethylpropyl)-

HRID 236303Notes

Reaction equation

HRID 236303 reaction equation
[NH2:1][C:2]1[C:3](=[O:15])[NH:4][C:5](=[O:14])[N:6]([CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[C:7]=1[NH2:8].[CH2:16](O)C>C(N)=O>[CH3:13][C:10]([CH3:11])([CH3:12])[CH2:9][N:6]1[C:7]2[N:8]=[CH:16][NH:1][C:2]=2[C:3](=[O:15])[NH:4][C:5]1=[O:14]

Participants

4

Reactant 2

HCID 702EthanolHCID 54164473HCID 54164473, compound

Product 1

HCID 30590001H-Purine-2,6-dione, 3,7-dihydro-3-(2,2-dimethylpropyl)-

Reagents, catalysts & solvents 1

HCID 713FormamideSolvent

Procedure

4.0 g of XXVIII was refluxed in 20 ml of formamide for 30 minutes. After cooling 30 ml of ethanol was added and the yellow crystals were filtered off and recrystallized from 15 ml of DMF. Yield 2.0 g (XXIX) NMR (see Table I).

Workup

  1. additionwas added
  2. filtrationthe yellow crystals were filtered off
  3. customrecrystallized from 15 ml of DMF

Sources & evidence

ORD record
ord-c92df7b19c854ad7a9369a3af5c847ca
Source dataset
uspto-grants-1987_02
Patent number
US04644001

Reaction notes

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