Diethyl Ether → 1H-Purine-2,6-dione, 3,7-dihydro-3-(2,2-dimethylpropyl)-8-methyl-

HRID 236304Notes

Reaction equation

HRID 236304 reaction equation
[NH2:1][C:2]1[C:3](=[O:15])[NH:4][C:5](=[O:14])[N:6]([CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[C:7]=1[NH2:8].C(Cl)(Cl)Cl.[CH3:20][CH2:21]OCC>C(O)(=O)C>[CH3:13][C:10]([CH3:11])([CH3:12])[CH2:9][N:6]1[C:7]2[N:8]=[C:20]([CH3:21])[NH:1][C:2]=2[C:3](=[O:15])[NH:4][C:5]1=[O:14]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 6212ChloroformHCID 54164473HCID 54164473, compound

Product 1

HCID 30590021H-Purine-2,6-dione, 3,7-dihydro-3-(2,2-dimethylpropyl)-8-methyl-

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

10.4 g of 5,6-diamino-1-(2,2-dimethylpropyl)-2,4-(1H,3H)-pyrimidine dione (XXVIII) was refluxed in 75 ml of acetic acid for 1 hour. 50 ml of chloroform was added and ether was then added slowly. The received crystals were filtered off. Yield 11.4 g. The amide was refluxed in 50 ml of 1N NaOH for 1 hour and then neutralized with 5N HCl. Yield 7.2 g (XXXIV). NMR (see Table I).

Workup

  1. filtrationThe received crystals were filtered off
  2. temperatureThe amide was refluxed in 50 ml of 1N NaOH for 1 hour

Sources & evidence

ORD record
ord-d7f0b2f37c4d4c2b8e2b4d902a9ebf5c
Source dataset
uspto-grants-1987_02
Patent number
US04644001

Reaction notes

Loading…