HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-cyclopropyl-3,7-dihydro-8-methyl-1H-purine-2,6-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1-cyclopropyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione | HCID 53690076 | — |
| Product | 3-cyclopropyl-3,7-dihydro-8-methyl-1H-purine-2,6-dione | HCID 20217053 | — |
Reaction Steps
A solution of 6.4 g of 1-cyclopropyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione (IV) in 20 ml of acetic acid was refluxed for 2 hours. The solution was evaporated. The received oil was refluxed in 40 ml of 2N NaOH and 10 ml of 5N NaOH for 1 hour and then neutralized with 5N HCl. The crystals were filtered off. Yield 1.85 g (26%) (XXXVI) NMR (see Table I).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04644001 |
| Source dataset | uspto-grants-1987_02 |
| ORD ID | ord-945ddb6c76414631b2f297afe3a1010f |
| Source note | uspto-grants-1987_02 |