4-(Trifluoromethyl)phenol → 2-(4-Trifluoromethyl-phenoxy)-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	4-(Trifluoromethyl)phenol	HCID 67874	—
Reactant	2-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide	HCID 67110887	—
Product	2-(4-Trifluoromethyl-phenoxy)-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide	HCID 67238470	68.5%

Reaction Steps

2-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide (50 mg, 0.13 mmol) was reacted with 4-trifluoromethyl phenol (43 mg, 0.26 mmol) to give the title compound (45 mg, 67%) after purification by column chromatography (gradient 12% to 100% EtOAc in n-hexane).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08691855B2
Source dataset	uspto-grants-2014_04
ORD ID	ord-f4438c6b8d81445ca58f25206c7989a8
Source note	uspto-grants-2014_04