4-tert-Butylphenol → 2-(4-tert-Butyl-phenoxy)-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	4-tert-Butylphenol	HCID 7393	—
Reactant	2-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide	HCID 67110887	—
Product	2-(4-tert-Butyl-phenoxy)-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide	HCID 67239672	51.4%

Reaction Steps

2-Chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide (50 mg, 0.13 mmol) was reacted with 4-tert-butyl phenol (40 mg, 0.26 mmol) to give the title compound (33 mg, 51%) after purification by column chromatography (gradient 12% to 100% EtOAc in n-hexane).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08691855B2
Source dataset	uspto-grants-2014_04
ORD ID	ord-d1793d265cc8490cb68db986ebd1ce72
Source note	uspto-grants-2014_04